imPS1485

The large-scale isotopomer mapping model imPS1485 for Escherichia coli contains a comprehensive reaction network consisting of 238 reactions and 184 metabolites and contains the reactions necessary for the production of amorphadiene from glucose by an engineered strain of E. coli. Cofacactor usage such as ATP, NAD, and NADP are included in the reactions, and the model contains a detailed biomass equation which proportionally drains the components of biomass (or their precursors) to account for cell growth. The model also contains symmetric metabolites such as succinate. The carbon numbering scheme follows that in the .mol files from KEGG, which for some molecules is non-standard by usual chemical numbering.

Suthers, P.F, A.P. Burgard, M.S. Dasika, F. Nowroozi, S. Van Dien, J.D. Keasling and C.D. Maranas (2007), "Metabolic flux elucidation for large-scale models using ¹³C labeled isotopes," Metabolic Engineering, 9(5-6), 387-405.

The model is licensed under a Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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